Amelogemesis Imperfecta has a genetic predisposition. The most frequently known causes of Amelogenesis Imperfecta are mutations in the ENAM gene. Amelogenesis Impefecta is most commonly inherited in an autosomal dominant pattern. This inheritance pattern type means that an individual only needs to inherit one copy of the mutated gene to result in having the disorder. The individual presents with extremely malformed enamel. Amelogenesis Imperfecta results from malfunction of enamel proteins (Ameloblastin, Enamelin, Tuftelin and Amelogenin). The majority of people with this disorder present with dental hypersensitivity and Enamel Hypoplasia.

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